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Immediate-type hypersensitivity includes anaphylaxis, serum sickness, atopy, etc. Immediate-type hypersensitivity appears shortly after the introduction of the antigen. The antigen-antibody reaction in tissues and liquid tissue media is involved in its development. It has the ability to be transmitted from one animal to another in a passive way, that is, by introducing the immune serum of sildenafil pills. In most cases, the immediate hypersensitivity state can be removed by desensitization.
One of the forms of altered reactivity is anaphylaxis (lat. aparnuax! a - a state of increased sensitivity of the body caused by repeated administration of foreign proteins (serum, antibiotics, etc.). The first dose of the antigen (protein) that causes hypersensitivity is called sensitizing, the second dose, from the introduction of which anaphylaxis develops, is resolving. The sensitizing dose is administered to animals subcutaneously, intraperitoneally, intravenously, intracardiac, the resolving dose is administered intravenously or intracardiac and in a larger dose than the sensitizing one. The state of hypersensitivity in animals does not develop immediately, but after a certain - incubation - period (8-21 days).
In rabbits, anaphylaxis is characterized by spasm of the terminal arteries of the pulmonary circulation and blockade of the pulmonary circulation, a drop in blood pressure in the systemic circulation, a slowdown in the activity of the heart, and a sharp expansion of the right ventricle. Death occurs from respiratory arrest and a drop in blood pressure.
A person with anaphylactic shock develops disorders of the cardiovascular system, spasm of smooth muscles, body temperature decreases by 1-4 ° C. Anaphylactic shock in humans occurs as a result of repeated injections of heterogeneous immune sera in the treatment of patients with various infectious diseases (diphtheria, tetanus, anthrax, anaerobic infection), as well as antibiotics (penicillin, etc.). It is characterized by a number of symptoms. shortness of sildenafil, rapid pulse, drop in blood pressure, decrease in body temperature, convulsions, bronchospasm, swelling, joint pain, rash on the body, etc. In some cases, shock ends in death.